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The Dickey laboratory then made use of an aerosolized Edition inside of a mouse model to substantiate the drug decreased mucin secretion and airway blockage by mucus. Importantly, SP9 did not have an affect on the sluggish-launch pathway for typical mucin secretion.
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"We developed up an image of just what the secretory equipment looked like and we knew every one of the major players," Dickey said. "As soon as we had an concept of how the many parts labored together, we established synaptotagmin-2 (Syt2) was the top protein to focus on to block mucin secretion since it only gets activated which has a high level of stimulation.
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